Abstract Search

ea0029p1163 | Nuclear receptors and Signal transduction | ICEECE2012

Protein metabolism in human skeletal muscle after 72 h fasting; increased muscle protein breakdown and impaired insulin signaling

Vendelbo M. , Jorgensen J. , Jessen N. , Moller N.

Background: Intermittent fasting increase maximum lifespan in several species and this effect is associated with reduced protein synthesis signaling. During fasting, a progressive loss of protein in human skeletal muscle is evident. Furthermore, fasting is associated with increased lipid oxidation and insulin resistance.Aim: To define which protein metabolic mechanisms are activated in skeletal muscle during fasting.Methods: We inv...

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ea0029p533 | Diabetes | ICEECE2012

Direct metabolic effects of locally administered lipopolysaccharide in the placebo controlled bilaterally infused human leg; decreased insulin sensitivity and insulin signaling with unaltered lipid and protein metabolism

Buhl M. , Bosnjak E. , Gjedsted J. , Nielsen R. , Jessen N. , Hafstrom T. , Vestergaard E. , Tonnesen E. , Moller N.

Introduction: In humans bacterial lipopolysaccharide (LPS/endotoxin) causes chronic low-grade and acute inflammatory responses, which decrease insulin sensitivity and may lead to chronic type 2 diabetes and acute stress diabetes. Systemic LPS invariably generates cytokine release, which triggers release of anti-insulin stress hormones and it is not known whether insulin resistance is secondary to stress hormones or LPS per se. Our study was designed to test whether local place...

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Endocrine Abstracts

Protein metabolism in human skeletal muscle after 72 h fasting; increased muscle protein breakdown and impaired insulin signaling

Direct metabolic effects of locally administered lipopolysaccharide in the placebo controlled bilaterally infused human leg; decreased insulin sensitivity and insulin signaling with unaltered lipid and protein metabolism

BiosciAbstracts